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Kidney Int Suppl. 1991 Dec;35:S72-9.

Mechanisms of disease in hemorrhagic fever with renal syndrome.

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Hematology-Oncology Service, Fitzsimons Army Medical Center Aurora, Colorado.


Hemorrhagic fever with renal syndrome (HFRS) is a dramatic illness characterized by fever, and variable degrees of circulatory failure, hemorrhage, and renal insufficiency. Hantaviruses are the cause of this syndrome. In its severe form, it is associated with significant mortality. Vascular dysfunction is the key physiologic derangement in this disorder. There is a growing body of evidence that suggests that immune mechanisms account for this derangement.

[Indexed for MEDLINE]

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