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Sheng Li Ke Xue Jin Zhan. 2006 Apr;37(2):103-7.

[Function of PAT family proteins in the lipid metabolism].

[Article in Chinese]

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Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100083, China.


Triglycerides are stored in intracellular lipid droplets in mammalian cells. Current evidences suggest that the intracellular lipid droplets are active participants in a variety of metabolic processes, and thus are considered as functional organelles in cells. The lipid droplet is composed of a triglyceride core surrounded by a phospholipid monolayer in which several proteins are embedded. Four of these proteins belong to a family of structurally related PAT protein, which includes perilipin, ADRP, TIP47 and S3-12. In this review, we summarize the functions of these proteins in the modulation of lipolysis and lipid droplets formation.

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