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J Immunol. 2006 Aug 1;177(3):1421-5.

Cutting edge: unique T cells that recognize citrullinated peptides are a feature of protein immunization.

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Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.


Abs against citrullinated proteins are present in patients with rheumatoid arthritis. In this study, we describe a unique cohort of T cells that selectively responded to citrullinated variants of two epitopes of hen egg-white lysozyme, a major and a minor one, bound to the MHC molecule, I-A(k). In addition, we show that when given an intact, unmodified lysozyme protein, dendritic cells and peritoneal macrophages presented citrullinated peptides and stimulated modification-specific T cells. Thus, presentation of citrullinated-peptide-MHC complex is a feature of immune responses to protein Ags.

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