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Cell Mol Life Sci. 2006 Sep;63(17):1933-6.

DNA methylation of fly genes and transposons.

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  • 1Dipartimento di Biologia Animale, Universit√† di Modena e Reggio Emilia, Via Campi 213/d, 41100 Modena, Italy. mandrioli.mauro@unimore.it

Abstract

The use of anti-5-methylcytosine antibodies in affinity columns allowed the identification of methylated sequences in the genome of Drosophila melanogaster adults. In view of the presence of transposable elements amongst the identified sequences, it has been suggested that DNA methylation is involved in transposon control in the fly genome. On the contrary, a reanalysis of these data furnishes several intriguing elements that could raise new questions about the role that DNA methylation plays in the fly genome. The aim of the present paper is to discuss some features that emerge from the analysis of the identified methylated sequences.

PMID:
16847580
DOI:
10.1007/s00018-006-6039-1
[PubMed - indexed for MEDLINE]

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