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Clin Microbiol Rev. 2006 Jul;19(3):546-57.

Epidemiology of human metapneumovirus.

Author information

  • 1Department of Pediatrics, Division of Infectious Diseases, Yale University School of Medicine, P.O. Box 208064, New Haven, CT 06520-8064, USA. jeffrey.kahn@yale.edu

Abstract

Since the discovery of human metapneumovirus (hMPV) in 2001, the virus has been identified worldwide. hMPV is a common respiratory pathogen, particularly in infants and young children. The virus is associated with both upper and lower respiratory tract infections and may be a trigger for asthma. At least two major genotypes of hMPV circulate during community outbreaks. Whether these genotypes represent distinct serotypes remains controversial. The major challenges faced by the medical and scientific communities are the understanding of the pathogenesis of hMPV disease and the development of a safe and effective vaccine to protect against infection and disease caused by this newly recognized respiratory virus.

PMID:
16847085
PMCID:
PMC1539100
DOI:
10.1128/CMR.00014-06
[PubMed - indexed for MEDLINE]
Free PMC Article
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