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Cell Biol Toxicol. 2006 Sep;22(5):323-9. Epub 2006 Jul 16.

Novel selenoorganic compounds as modulators of oxidative stress in blood platelets.

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1
Department of General Biochemistry, University of Lodz, Banacha 12/16, 90-237, Lodz, Poland. juszczak@biol.uni.lodz.pl

Abstract

Many selenoorganic compounds play an important role in biochemical processes and act as antioxidants, enzyme inhibitors, or drugs. The effects of five new synthesized selenoorganic compounds (2-(5-chloro-2-pyridyl)-7-azabenzisoselenazol-3(2H)-one; 2-phenyl-7-azabenzisoselenazol-3(2H)-one; 2-(pyridyl)-7-azabenzisoselenazol-3(2H)-one; 7-azabenzisoselenazol-3(2H)-one; bis(2-aminophenyl) diselenide) on oxidative changes in human blood platelets and in plasma were studied in vitro and compared with those of ebselen, a well known antioxidant. Our studies demonstrated that bis(2-aminophenyl) diselenide has distinctly protective effects against oxidative stress in blood platelets and in plasma. It might have greater biological relevance and stronger pharmacological effects than ebselen.

PMID:
16845609
DOI:
10.1007/s10565-006-0091-3
[Indexed for MEDLINE]
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