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J Invest Dermatol. 2006 Aug;126(8):1691-2.

Plenty new under the sun.

Author information

1
Department of Dermatology, University of Edinburgh, Edinburgh United Kingdom. jonathan.rees@ed.ac.uk

Abstract

Variation at the melanocortin 1 receptor (MC1R) is very common in most non-African world populations. A range of variants predispose to skin cancer, including melanoma. What remains unclear are the mechanisms linking gene variation with sun sensitivity or tumor risk. In particular, it remains unclear whether pigmentary effects of the MC1R can account for all of the increase in cancer risk.

PMID:
16845407
DOI:
10.1038/sj.jid.5700345
[Indexed for MEDLINE]
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