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Nat Struct Mol Biol. 2006 Aug;13(8):751-2. Epub 2006 Jul 16.

Architecture of the SARS coronavirus prefusion spike.

Author information

1
Viral Diseases Division, National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, Manitoba, R3E 3R2, Canada.

Abstract

The emergence in 2003 of a new coronavirus (CoV) responsible for the atypical pneumonia termed severe acute respiratory syndrome (SARS) was a stark reminder that hitherto unknown viruses have the potential to cross species barriers to become new human pathogens. Here we describe the SARS-CoV 'spike' structure determined by single-particle cryo-EM, along with the docked atomic structures of the receptor-binding domain and prefusion core.

PMID:
16845391
DOI:
10.1038/nsmb1123
[Indexed for MEDLINE]
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