Format

Send to

Choose Destination
Nat Neurosci. 2006 Aug;9(8):993-5. Epub 2006 Jul 16.

IGF-1 receptor is essential for the establishment of hippocampal neuronal polarity.

Author information

1
Departamento de Química Biológica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba y Centro de Investigaciones en Química Biológica de Córdoba (CIQUIBIC), Consejo de Investigaciones Científicas y Técnicas (CONICET), Córdoba, Argentina.

Abstract

How a neuron becomes polarized remains largely unknown. Results obtained with a function-blocking antibody and an siRNA targeting the insulin-like growth factor-1 (IGF-1) receptor suggest that an essential step in the establishment of hippocampal neuronal polarity and the initiation of axonal outgrowth is the activation of the phosphatidylinositol 3-kinase (PI3k)-Cdc42 pathway by the IGF-1 receptor, but not by the TrkA or TrkB receptors.

PMID:
16845384
DOI:
10.1038/nn1742
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center