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Nat Cell Biol. 2006 Aug;8(8):891-3. Epub 2006 Jul 16.

Regulation of cytokinesis by spindle-pole bodies.

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1
Wadsworth Center, Albany, NY 12201-0509, USA.

Abstract

In the fission yeast Schizosaccharomyces pombe, cytokinesis is thought to be controlled by the daughter spindle-pole body (SPB) through a regulatory pathway named the septation initiation network (SIN). Here, we demonstrate that laser ablation of both, but not a single SPB, results in failure of cytokinesis. Ablation of only the daughter SPB often leads to activation of the SIN on the mother SPB and successful cytokinesis. Thus, either SPB can drive cytokinesis.

PMID:
16845379
DOI:
10.1038/ncb1449
[Indexed for MEDLINE]
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