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Cancer Genet Cytogenet. 1991 Nov;57(1):11-7.

Cytogenetics of a renal cell carcinoma in a 17-month-old child. Evidence for Xp11.2 as a recurring breakpoint.

Author information

1
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235-9063.

Abstract

A renal cell carcinoma from a 17-month-old boy with a history of maternal hydrocarbon exposure was found to have a 46,Y,t(X;17)(p11.2;q25) karyotype. Although this translocation has not previously been reported, other translocations involving Xp11.2 have been described, suggesting that this may represent a non-random breakpoint involved in the pathogenesis of childhood renal cell carcinoma. Both chromosomes 3 in the tumor were normal by both karyotype and RFLP analysis.

PMID:
1684532
DOI:
10.1016/0165-4608(91)90184-v
[Indexed for MEDLINE]

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