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Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W683-5.

Quadfinder: server for identification and analysis of quadruplex-forming motifs in nucleotide sequences.

Author information

1
GN Ramachandran Knowledge Center for Genome Informatics, Institute of Genomics and Integrative Biology CSIR, Mall Road, Delhi 110 007, India.

Abstract

G-quadruplex secondary structures, which play a structural role in repetitive DNA such as telomeres, may also play a functional role at other genomic locations as targetable regulatory elements which control gene expression. The recent interest in application of quadruplexes in biological systems prompted us to develop a tool for the identification and analysis of quadruplex-forming nucleotide sequences especially in the RNA. Here we present Quadfinder, an online server for prediction and bioinformatics of uni-molecular quadruplex-forming nucleotide sequences. The server is designed to be user-friendly and needs minimal intervention by the user, while providing flexibility of defining the variants of the motif. The server is freely available at URL http://miracle.igib.res.in/quadfinder/.

PMID:
16845097
PMCID:
PMC1538896
DOI:
10.1093/nar/gkl299
[Indexed for MEDLINE]
Free PMC Article

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