siVirus: web-based antiviral siRNA design software for highly divergent viral sequences

Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W448-50. doi: 10.1093/nar/gkl214.

Abstract

siVirus (http://siVirus.RNAi.jp/) is a web-based online software system that provides efficient short interfering RNA (siRNA) design for antiviral RNA interference (RNAi). siVirus searches for functional, off-target minimized siRNAs targeting highly conserved regions of divergent viral sequences. These siRNAs are expected to resist viral mutational escape, since their highly conserved targets likely contain structurally/functionally constrained elements. siVirus will be a useful tool for designing optimal siRNAs targeting highly divergent pathogens, including human immunodeficiency virus (HIV), hepatitis C virus (HCV), influenza virus and SARS coronavirus, all of which pose enormous threats to global human health.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents / chemistry
  • Antiviral Agents / chemistry*
  • Base Sequence
  • Conserved Sequence
  • Genetic Variation
  • Internet
  • RNA Interference*
  • RNA Viruses / genetics
  • RNA, Small Interfering / chemistry*
  • RNA, Viral / chemistry*
  • Software*

Substances

  • Anti-HIV Agents
  • Antiviral Agents
  • RNA, Small Interfering
  • RNA, Viral