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Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W350-5.

DILIMOT: discovery of linear motifs in proteins.

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1
EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany.

Abstract

Discovery of protein functional motifs is critical in modern biology. Small segments of 3-10 residues play critical roles in protein interactions, post-translational modifications and trafficking. DILIMOT (DIscovery of LInear MOTifs) is a server for the prediction of these short linear motifs within a set of proteins. Given a set of sequences sharing a common functional feature (e.g. interaction partner or localization) the method finds statistically over-represented motifs likely to be responsible for it. The input sequences are first passed through a set of filters to remove regions unlikely to contain instances of linear motifs. Motifs are then found in the remaining sequence and ranked according to a statistic that measure over-representation and conservation across homologues in related species. The results are displayed via a visual interface for easy perusal. The server is available at http://dilimot.embl.de.

PMID:
16845024
PMCID:
PMC1538856
DOI:
10.1093/nar/gkl159
[Indexed for MEDLINE]
Free PMC Article
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