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Curr Opin Struct Biol. 2006 Aug;16(4):531-43. Epub 2006 Jul 14.

The architectonics of programmable RNA and DNA nanostructures.

Author information

1
Department of Chemistry and Biochemistry, Material Research Laboratory, Biomolecular Science and Engineering Program, University of California, Santa Barbara, CA 93106-9510, USA. jaeger@chem.ucsb.edu

Abstract

The past several years have witnessed the emergence of a new world of nucleic-acid-based architectures with highly predictable and programmable self-assembly properties. For almost two decades, DNA has been the primary material for nucleic acid nanoconstruction. More recently, the dramatic increase in RNA structural information led to the development of RNA architectonics, the scientific study of the principles of RNA architecture with the aim of constructing RNA nanostructures of any arbitrary size and shape. The remarkable modularity and the distinct but complementary nature of RNA and DNA nanomaterials are revealed by the various self-assembly strategies that aim to achieve control of the arrangement of matter at a nanoscale level.

PMID:
16843653
DOI:
10.1016/j.sbi.2006.07.001
[Indexed for MEDLINE]

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