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Ultrasonics. 2006 Dec 22;44 Suppl 1:e21-5. Epub 2006 Jun 30.

Sonoporation, anti-cancer drug and antibody delivery using ultrasound.

Author information

1
Department of Physics, University of Vermont, Burlington, VT 05405, USA. Jun-Ru.Wu@uvm.edu <Jun-Ru.Wu@uvm.edu>

Abstract

It has been shown experimentally in cell suspensions that sonoporation could be used to deliver the anti-cancer drug Adriamycin hydrochloride (ADR) into Jurkat lymphocytes and that it could also be used to deliver goat anti-rabbit IgG and anti-mouse IgD, antibodies into human peripheral blood mononuclear cells (PBMC) and Jurkat lymphocytes. When ADR was delivered, the delivery efficiency reached 4.80+/-2.04% and control baseline (no ultrasound and no ADR) was 0.17+/-0.14%. When anti-rabbit IgD was delivered, the efficiencies were 34.90+/-1.80% (control baseline was 1.33+/-0.31%) and 32.50+/-4.36% (control baseline was 1.66+/-0.06%) respectively for Jurkat cells and PBMC. When goat anti-rabbit IgG was delivered, the efficiencies were 78.60+/-3.60% (control baseline was 1.60+/-0.00%) and 57.50+/-4.23% (control baseline was 11.30+/-0.81%) respectively for Jurkat cells and PBMC.

PMID:
16843514
DOI:
10.1016/j.ultras.2006.06.033
[Indexed for MEDLINE]

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