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J Neuroimmunol. 2006 Sep;178(1-2):149-55. Epub 2006 Jul 13.

Antibrain antibodies in children with autism and their unaffected siblings.

Author information

1
Department of Neurology, Johns Hopkins University School of Medicine, Jefferson Street Building 124, 600 N. Wolfe Street, Baltimore, MD 21287-1000, USA. hsinger@jhmi.edu

Abstract

Serum autoantibodies to human brain, identified by ELISA and Western immunoblotting, were evaluated in 29 children with autism spectrum disorder (22 with autistic disorder), 9 non-autistic siblings and 13 controls. More autistic subjects than controls had bands at 100 kDa in caudate, putamen and prefrontal cortex (p<0.01) as well as larger peak heights of bands at 73 kDa in the cerebellum and cingulate gyrus. Both autistic disorder subjects and their matched non-autistic siblings had denser bands (peak height and/or area under the curve) at 73 kDa in the cerebellum and cingulate gyrus than did controls (p<0.01). Results suggest that children with autistic disorder and their siblings exhibit differences compared to controls in autoimmune reactivity to specific epitopes located in distinct brain regions.

PMID:
16842863
DOI:
10.1016/j.jneuroim.2006.05.025
[Indexed for MEDLINE]
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