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Mini Rev Med Chem. 2006 Jul;6(7):765-70.

Myostatin: biology and clinical relevance.

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  • 1Adult stem cells and Facio Scapulo Humeral dystrophy, CRBM, CNRS FRE 2593, 1919 Route de Mende, 34293 Montpellier Cedex 5, France.


Myostatin is a negative regulator of muscle mass. Important advances in our understanding of the complex biology of this factor have revealed the therapeutic potential of antagonizing the myostatin pathway. Here we present the rationale for evaluating anti-myostatin therapies in human muscle-wasting disorders.

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