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Cell. 2006 Jul 14;126(1):27-9.

OPA1 and PARL keep a lid on apoptosis.

Author information

1
Apoptosis and tumour physiology laboratory, Cancer Research UK, The Beatson Institute for Cancer Research, Glasgow, Scotland G61 1BD, UK. e.gottlieb@beatson.gla.ac.uk

Abstract

A change in the shape of mitochondrial cristae must take place to attain rapid and complete release of cytochrome c during apoptosis. In this issue of Cell, Cipolat et al. and Frezza et al. (2006) show that a rhomboid intramembrane protease PARL and a dynamin-related protein OPA1 are critical regulators of cristae remodeling.

PMID:
16839872
DOI:
10.1016/j.cell.2006.06.030
[Indexed for MEDLINE]
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