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Cell. 2006 Jul 14;126(1):22-4.

It takes a PHD to read the histone code.

Author information

  • 1Department of Biochemistry, South Parks Road, Oxford, OX1 3QU, UK. jane.mellor@bioch.ox.ac.uk

Abstract

The pattern of histone modifications, called the histone code, influences transitions between chromatin states and the regulation of transcriptional activity. Four recent papers describe how plant homeodomain (PHD) finger proteins read part of this code. The PHD finger may promote both gene expression and repression through interactions with trimethylated lysine 4 on histone 3 (H3K4), a universal modification at the beginning of active genes.

PMID:
16839870
DOI:
10.1016/j.cell.2006.06.028
[PubMed - indexed for MEDLINE]
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