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Biol Psychiatry. 2007 Feb 1;61(3):415-8. Epub 2006 Jul 12.

Probability of obsessive and compulsive symptoms in Huntington's disease.

Author information

1
Department of Psychiatry, University of Iowa, Iowa City, Iowa 52242-1000, USA. leigh-beglinger@uiowa.edu

Abstract

BACKGROUND:

The purpose of this study was to examine the probability of obsessive and compulsive (OC) symptoms across stages of Huntington's disease (HD) with both cross sectional and longitudinal data.

METHODS:

We present the largest sample to date of individuals at risk for HD (N = 3964). Obsessive and compulsive symptoms were assessed with the Unified Huntington's Disease Rating Scale OC items.

RESULTS:

The probability of meeting the threshold for obsessions and compulsions increased with greater disease severity. Those with no motor abnormalities ("at risk") had a 7% probability of obsessions and a 3.5% probability of compulsions; the peak probability for obsessions (24%) and compulsions (12%) occurred in patients with advanced disease with significant functional disability.

CONCLUSIONS:

The probability of OC symptoms is more than three times greater by stages 3 and 4 (clearly manifest disease) than in our at-risk group with no apparent motor abnormalities.

PMID:
16839521
DOI:
10.1016/j.biopsych.2006.04.034
[Indexed for MEDLINE]
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