Format

Send to

Choose Destination
Am J Med Genet A. 2006 Dec 1;140(23):2530-5.

The genetic basis of tooth development and dental defects.

Author information

1
Institute of Biotechnology, University of Helsinki, Helsinki, Finland. irma.thesleff@helsinki.fi

Abstract

More than 300 genes have so far been associated with tooth development, mainly in mouse embryos. The majority of them are associated with conserved signaling pathways mediating cellular communication, in particular between epithelial and mesenchymal tissues. Necessary functions of many signals, receptors and transcription factors have been demonstrated in mice, and mutations causing dental defects in humans have been identified in several genes.

PMID:
16838332
DOI:
10.1002/ajmg.a.31360
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center