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Exp Oncol. 2006 Jun;28(2):132-5.

Application of DNA from mushroom Pleurotus ostreatus for cancer biotherapy: a pilot study.

Author information

1
R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kyiv 03022, Ukraine. sergeyolishevsky@yahoo.com

Abstract

AIM:

In present work, the attempt to study immunomodulatory activity and biotherapeutical potential of DNA isolated from the fruit body of P. ostreatus was made.

METHODS:

The efficacy of biotherapeutic application of mushroom DNA was evaluated on the BALB/c mice with subcutaneously transplanted Ehrlich carcinoma. The effect of Pleurotus ostreatus DNA on NK activity was studied in vitro using nonspecific cytotoxicity assay.

RESULTS:

Application of mushroom DNA resulted in augmentation of NK cytotoxic activity in vitro and significant increase of the life span of mice with solid Ehrlich carcinoma.

CONCLUSION:

The observed effects of P. ostreatus DNA administration can be probably explained by the presence of immunostimulatory unmethylated CpG motifs in DNA.

PMID:
16837904
[Indexed for MEDLINE]
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