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Vaccine. 2006 Nov 10;24(44-46):6594-6. Epub 2006 Jun 6.

Fitness costs limit escape from cytotoxic T lymphocytes by influenza A viruses.

Author information

1
Department of Virology and WHO National Influenza Center, Erasmus Medical Center, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands.

Abstract

The use of cytotoxic T lymphocyte (CTL)-inducing vaccines could afford both homo- and heterosubtypic immunity. However, amino acid variation in CTL epitopes associated with escape from CTL-mediated immunity might undermine the use of these vaccines. To assess the impact of amino acid substitutions in highly conserved epitopes on viral fitness and recognition by specific CTL, we performed a mutational analysis of various CTL epitopes. Our findings indicated that fitness costs limited variation in functionally constrained epitopes, especially at anchor residues.

PMID:
16837112
DOI:
10.1016/j.vaccine.2006.05.051
[Indexed for MEDLINE]

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