A new method for asperphenamate synthesis and its antimicrobial activity evaluation

Armando Mateus Pomini; Dalva Trevisan Ferreira; Raimundo Braz-Filho; Halha Ostrensky Saridakis; Wanderley Schmitz; Noemia Kazue Ishikawa; Milton Faccione

doi:10.1080/14786410500059573

A new method for asperphenamate synthesis and its antimicrobial activity evaluation

Nat Prod Res. 2006 May 20;20(6):537-41. doi: 10.1080/14786410500059573.

Authors

Armando Mateus Pomini¹, Dalva Trevisan Ferreira, Raimundo Braz-Filho, Halha Ostrensky Saridakis, Wanderley Schmitz, Noemia Kazue Ishikawa, Milton Faccione

Affiliation

¹ Universidade Estadual de Londrina - CCE - Depto. de Química, 86.051-970, Londrina PR, Brazil.

PMID: 16835084
DOI: 10.1080/14786410500059573

Abstract

Asperphenamate is a natural phenylalanine derivative. This compound was produced through a new, two-step synthetic route. It was also evaluated by the antimicrobial activity of the pure substance against Escherichia coli, Staphylococcus aureus and Cladosporium herbarum.

MeSH terms

Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology
Antifungal Agents / chemical synthesis*
Antifungal Agents / chemistry
Antifungal Agents / pharmacology
Cladosporium / drug effects
Escherichia coli / drug effects
Gas Chromatography-Mass Spectrometry
Microbial Sensitivity Tests
Nuclear Magnetic Resonance, Biomolecular
Phenylalanine / analogs & derivatives*
Phenylalanine / chemical synthesis
Phenylalanine / chemistry
Phenylalanine / pharmacology
Spectrophotometry, Infrared
Staphylococcus aureus / drug effects

Substances

Anti-Bacterial Agents
Antifungal Agents
Phenylalanine
asperphenamate