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Breast Cancer Res. 2006;8(4):105.

Snail in the frame of malignant tumor recurrence.

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1
Unit of Molecular and Cellular Oncology, Department for Molecular Biomedical Research, VIB-Ghent University, Belgium.

Abstract

Snail plays an important role in the epithelial-to-mesenchymal transition during development and in tumor progression. Induction of Snail expression coincides with drastic morphological changes in cultured epithelial cells. Recently, a new role for Snail in tumor recurrence has been inferred from a reversible HER-2/neu-induced breast cancer mouse model. Comparative transcriptome analysis of human primary breast cancers suggests that elevated Snail expression is correlated with decreased relapse-free survival. Further characterization of Snail as master regulator in this process might enhance our understanding of the molecular and cellular changes during and after breast tumor recurrence.

PMID:
16834762
PMCID:
PMC1779474
DOI:
10.1186/bcr1521
[Indexed for MEDLINE]
Free PMC Article
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