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J Am Chem Soc. 2006 Jul 19;128(28):9022-3.

Structure-based discovery of glycolipids for CD1d-mediated NKT cell activation: tuning the adjuvant versus immunosuppression activity.

Author information

1
The Scripps Research Institute, La Jolla, California 92037, USA.

Abstract

Introduction of an aromatic group into the fatty acyl chain of alpha-GalCer modulates the activity and selectivity of IFN-gamma/IL-4 secretion through CD1d-mediated activation of NKT cells. Compound 14-16 are more potent than alpha-Galcer and biased for IFN-gamma than for IL-4. These new glycolipids may find use as adjuvants or as antimetastatic agents.

PMID:
16834361
DOI:
10.1021/ja062740z
[Indexed for MEDLINE]

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