The results of calculations outlining aspects of the chemistry of element 112, element 114, and element 118 are compared to those for their 6th row analogues Hg, Pb, and Rn, respectively. Element 112 and element 114 are found to be relatively inert as compared to Hg and Pb, while element 118 is much more active than radon. Spin-orbit coupling plays a dominant role in this behavior.