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Neurology. 2006 Jul 11;67(1):159-60.

Diffuse cerebral vasoconstriction (Call-Fleming syndrome) and stroke associated with antidepressants.

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  • 1Department of Neurology, Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA.


Call-Fleming syndrome is a reversible segmental vasoconstriction of cerebral arteries manifested by a "thunderclap" headache and focal neurologic symptoms. Although of unknown etiology, it has been reported in association with vasoactive sympathomimetic drugs. The authors report Call-Fleming syndrome in two patients with history of antidepressant use. Although the association is hypothetical, the authors suggest consideration of Call-Fleming syndrome in patients presenting with headache, focal deficits, and evidence of cerebral ischemia during antidepressant use.

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