Format

Send to

Choose Destination
Cereb Cortex. 2007 Jun;17(6):1283-91. Epub 2006 Jul 10.

Cytochrome oxidase and neurofilament reactivity in monocularly deprived human primary visual cortex.

Author information

1
Department of Psychology, Life Sciences Centre, Dalhousie University, Halifax, Nova Scotia, Canada. kevin.duffy@dal.ca

Abstract

Previous studies of human primary visual cortex (V1) have demonstrated a significant eye-specific decrease in cytochrome oxidase (CO) staining following monocular enucleation. We have extended these results by examining CO staining and neurofilament labeling in V1 from a patient with long-standing monocular blindness. A pattern of reduced neurofilament reactivity was found to align with pale CO-stained ocular dominance columns. Neurons located within deprived ocular dominance columns were significantly smaller compared with those in nondeprived columns. A spatial analysis of the relationship between CO blobs and ocular dominance columns revealed that both deprived and nondeprived blobs tended to align with the centers of ocular dominance columns.

PMID:
16831856
PMCID:
PMC2628812
DOI:
10.1093/cercor/bhl038
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center