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Nat Rev Mol Cell Biol. 2006 Jul;7(7):529-39.

RNA-quality control by the exosome.

Author information

1
Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, EH9 3JR, UK. d.tollervey@ed.ac.uk

Abstract

The exosome complex of 3'-->5' exonucleases is an important component of the RNA-processing machinery in eukaryotes. This complex functions in the accurate processing of nuclear RNA precursors and in the degradation of RNAs in both the nucleus and the cytoplasm. However, it has been unclear how different classes of substrate are distinguished from one another. Recent studies now provide insights into the regulation and structure of the exosome, and they reveal striking similarities between the process of RNA degradation in bacteria and eukaryotes.

PMID:
16829983
DOI:
10.1038/nrm1964
[Indexed for MEDLINE]

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