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Nat Rev Mol Cell Biol. 2006 Jul;7(7):484-94.

The biogenesis and regulation of telomerase holoenzymes.

Author information

1
Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3204, USA. kcollins@berkeley.edu

Abstract

Chromosome stability requires a dynamic balance of DNA loss and gain in each terminal tract of telomeric repeats. Repeat addition by a specialized reverse transcriptase, telomerase, has an important role in maintaining this equilibrium. Insights that have been gained into the cellular pathways for biogenesis and regulation of telomerase ribonucleoproteins raise new questions, particularly concerning the dynamic nature of this unique polymerase.

PMID:
16829980
PMCID:
PMC2915765
DOI:
10.1038/nrm1961
[Indexed for MEDLINE]
Free PMC Article

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