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Nat Rev Mol Cell Biol. 2006 Jul;7(7):473-83.

Reading protein modifications with interaction domains.

Author information

1
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada.

Abstract

Proteins are controlled by a vast and dynamic array of post-translational modifications, many of which create binding sites for specific protein-interaction domains. We propose that these domains, working together, read the state of the proteome and therefore couple post-translational modifications to cellular organization. We also identify common strategies through which modification-dependent interactions synergize to regulate cell behaviour.

PMID:
16829979
DOI:
10.1038/nrm1960
[Indexed for MEDLINE]
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