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Nat Neurosci. 2006 Aug;9(8):996-8. Epub 2006 Jul 9.

UNC5A promotes neuronal apoptosis during spinal cord development independent of netrin-1.

Author information

1
Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California 95064, USA.

Abstract

In addition to their role as chemorepellent netrin-1 receptors, UNC5 proteins may mediate cell death because they induce apoptosis in cultured cells. To test this in vivo, we generated Unc5a (formerly Unc5h1) knockout mice and found that this deletion decreased apoptosis and increased the number of neurons in the spinal cord. In contrast, loss of netrin-1 (Ntn1) did not affect the amount of apoptosis, suggesting that NTN1 is not required for neuronal apoptosis in vivo.

PMID:
16829956
DOI:
10.1038/nn1736
[Indexed for MEDLINE]

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