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Contemp Clin Trials. 2007 Feb;28(2):182-91. Epub 2006 Jul 7.

Design and analysis of stepped wedge cluster randomized trials.

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Fred Hutchinson Cancer Research Center, Seattle, WA, United States.


Cluster randomized trials (CRT) are often used to evaluate therapies or interventions in situations where individual randomization is not possible or not desirable for logistic, financial or ethical reasons. While a significant and rapidly growing body of literature exists on CRTs utilizing a "parallel" design (i.e. I clusters randomized to each treatment), only a few examples of CRTs using crossover designs have been described. In this article we discuss the design and analysis of a particular type of crossover CRT - the stepped wedge - and provide an example of its use.

[Indexed for MEDLINE]

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