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Magn Reson Chem. 2006 Jul;44 Spec No:S101-7.

NMR determination that an extended BH3 motif of pro-apoptotic BID is specifically bound to BCL-XL.

Author information

1
The New York Structural Biology Center, 89 Convent Avenue, New York, NY 10027-7556, USA.

Abstract

The BH3 motif of the pro-survival family of proteins, BCL, is also present in pro-apoptotic proteins like BID and BAX. Homo- and hetero-oligomerization interactions of the BH3 motif are generally recognized as the critical component of their apoptotic activities. In full-length BID, the putative hydrophobic binding surface of its BH3 motif is substantially occluded by intramolecular contacts, many of which are removed on BID's transformation to tBID by cleavage with caspase 8, required for tBID's pro-apoptotic action on mitochondria, thereby releasing cytochrome c.

PMID:
16826547
PMCID:
PMC2365746
DOI:
10.1002/mrc.1856
[Indexed for MEDLINE]
Free PMC Article

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