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J Infect Dis. 2006 Aug 1;194(3):365-9. Epub 2006 Jun 20.

Deficient transendothelial migration of leukocytes in Q fever: the role played by interleukin-10.

Author information

1
Unité des Rickettsies, Centre National de la Recherche Scientifique, Université de la Mediterranée, Institut Fédératif de Recherche 48, Faculté de Médecine, Marseille, France.

Abstract

Chronic Q fever is characterized by deficient cell-mediated immune response, lack of granulomas, and dysregulation of the cytokine network. Altered transendothelial migration (TM) of peripheral-blood mononuclear cells might account for impaired immune response. TM of lymphocytes and monocytes was decreased in patients with Q fever endocarditis, compared with that in patients recovering from acute Q fever and in control subjects. This defect is related to interleukin (IL)-10, a cytokine involved in the chronic evolution of the disease; neutralizing anti-IL-10 antibodies corrected TM of mononuclear cells from patients with Q fever endocarditis. IL-10 may account for deficient protective immunity in patients with Q fever endocarditis by impairing TM.

PMID:
16826485
DOI:
10.1086/505227
[Indexed for MEDLINE]

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