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Behav Genet. 2006 Nov;36(6):845-57. Epub 2006 Jul 7.

Heritability and reliability of P300, P50 and duration mismatch negativity.

Author information

1
Social, Genetic Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College London, PO80, De Crespigny Park, London, SE5 8AF, UK. spgemhh@iop.kcl.ac.uk

Abstract

BACKGROUND:

Event-related potentials (ERPs) have been suggested as possible endophenotypes of schizophrenia. We investigated the test-retest reliabilities and heritabilities of three ERP components in healthy monozygotic and dizygotic twin pairs.

METHODS:

ERP components (P300, P50 and MMN) were recorded using a 19-channel electroencephalogram (EEG) in 40 healthy monozygotic twin pairs, 19 of them on two separate occasions, and 30 dizygotic twin pairs. Zygosity was determined using DNA genotyping.

RESULTS:

High reliabilities were found for the P300 amplitude and its latency, MMN amplitude, and P50 suppression ratio components. ICC=0.86 and 0.88 for the P300 amplitude and P300 latency respectively. Reliability of MMN peak amplitude and mean amplitude were 0.67 and 0.66 respectively. P50 T/C ratio reliability was 0.66. Model fitting analyses indicated a substantial heritability or familial component of variance for these ERP measures. Heritability estimates were 63 and 68% for MMN peak amplitude and mean amplitude respectively. For P50 T/C ratio, 68% heritability was estimated. P300 amplitude heritability was estimated at 69%, and while a significant familiality effect was found for P300 latency there was insufficient power to distinguish between shared environment and genetic factors.

CONCLUSIONS:

The high reliability and heritability of the P300 amplitude, MMN amplitude, and P50 suppression ratio components supports their use as candidate endophenotypes for psychiatric research.

PMID:
16826459
DOI:
10.1007/s10519-006-9091-6
[Indexed for MEDLINE]

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