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J Proteome Res. 2006 Jul;5(7):1776-84.

Efficient high-throughput discovery of large peptidic hormones and biomarkers.

Author information

1
Amylin Pharmaceuticals, Inc., 9360 Towne Centre Dr., San Diego California 92121, USA. staylor@amylin.com

Abstract

A novel approach is presented for the simultaneous identification and relative quantification of secreted peptides, particularly those that have been historically difficult to analyze in a concerted manner. Peptides exceeding 60 residues with various degrees of post-translational modification were identified on a liquid chromatographic time scale. The approach demonstrates high efficiency pattern-based recognition analysis of complex neuroendocrine peptide sets and enables rapid identification of biomarkers from biological material.

PMID:
16823986
DOI:
10.1021/pr0600982
[Indexed for MEDLINE]

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