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J Am Anim Hosp Assoc. 2006 Jul-Aug;42(4):269-76.

Long-term efficacy of trilostane administered twice daily in dogs with pituitary-dependent hyperadrenocorticism.

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Veterinary Teaching Hospital, Veterinary School, Complutense University of Madrid, Madrid, Spain.


Trilostane is considered an efficacious and safe medication for canine pituitary-dependent hyperadrenocorticism (PDH). Its recommended frequency of administration is once daily. In this prospective study, the efficacy, toxicity, and long-term outcome of trilostane administered twice daily per os were evaluated in 44 dogs with PDH. Mean initial dose was 3.1 mg/kg q 12 hours, and mean final dose was 3.2 mg/kg q 12 hours. The final total daily dose was lower than previously reported for once-daily administration. The mean survival time for affected dogs was 930 days.

[Indexed for MEDLINE]

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