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Curr Opin Biotechnol. 2006 Aug;17(4):394-9. Epub 2006 Jul 5.

Mapping protein-protein interactions by mass spectrometry.

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The Ottawa Institute of Systems Biology, Ottawa, ON, Canada.


Mass spectrometry is currently at the forefront of technologies for mapping protein-protein interactions, as it is a highly sensitive technique that enables the rapid identification of proteins from a variety of biological samples. When used in combination with affinity purification and/or chemical cross-linking, whole or targeted protein interaction networks can be elucidated. Several methods have recently been introduced that display increased specificity and a reduced occurrence of false-positives. In the future, information gained from human protein interaction studies could lead to the discovery of novel pathway associations and therapeutic targets.

[Indexed for MEDLINE]

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