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Clin Exp Med. 2006 Jun;6(2):49-52.

Autoantibodies to the ribosomal P proteins in systemic lupus erythematosus.

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1
Department of Medicine, Oklahoma University Health Sciences Center and Clinical Immunological Laboratory, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA. morris-reichlin@omrf.ouhsc.edu

Abstract

This paper describes the clinical significance of antibodies to the ribosomal P proteins in systemic lupus erythematosus. It appears that liver disease due to the lupus process and not attributable to viral infection, alcohol or drugs is associated with anti-ribosomal P. In addition, there is a strong relationship to central nervous system disease and nephritis of antibodies to ribosomal P proteins. The prevalence of the anti-P antibodies is strongly related to disease activity wherein disease remission is associated with disappearance of anti-P antibodies. These phenomena taken together suggest an immunopathogenic role for anti-P antibodies. This idea is strongly supported by the observation that immunoglobulin G containing antiribosomal P activity binds and penetrates living cells with profoundly inhibitory effects on protein synthesis. Finally, a new era of research has been uncovered by the observation that in 54 of 55 instances normal sera passed over a ribosome-sepharose column unmasks anti-P antibodies, which can be eluted from the ribosome column with 3.0 M magnesium chloride. This suggests that anti-idiotypes regulate the expression of anti-P antibodies in normal persons and in lupus patients this regulation is ineffective, with the development of free anti-P antibodies in a proportion of patients with active disease.

PMID:
16820990
DOI:
10.1007/s10238-006-0094-7
[Indexed for MEDLINE]
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