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Cytokine Growth Factor Rev. 2006 Aug;17(4):217-23. Epub 2006 Jul 3.

Matrix metalloproteinase-8: cleavage can be decisive.

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1
Department for Molecular Biomedical Research, Flanders Interuniversity Institute for Biotechnology and Ghent University, FSVM Building, Technologiepark 927, B-9052 Ghent (Zwijnaarde), Belgium. Philippe.VanLint@dmbr.UGent.be

Abstract

Matrix metalloproteinase-8 (MMP-8), also known as collagenase-2 or neutrophil collagenase, was long thought to be expressed solely by maturing neutrophils, and functionally restricted to ECM breakdown. Recent experiments, however, have revealed that this protease can be expressed by a wide variety of cell types and that it plays an important regulatory role in both acute and chronic inflammation. This review intends to give the reader an overview of the most interesting recent findings concerning the role of MMP-8 in inflammation and in cancer progression.

PMID:
16820317
DOI:
10.1016/j.cytogfr.2006.04.001
[Indexed for MEDLINE]
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