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Trends Ecol Evol. 2006 Oct;21(10):569-75. Epub 2006 Jul 3.

The genomic rate of adaptive evolution.

Author information

1
National Evolutionary Synthesis Center, Durham, NC 27705, USA. a.c.eyre-walker@sussex.ac.uk

Abstract

The role of positive darwinian selection in evolution at the molecular level has been keenly debated for many years, with little resolution. However, a recent increase in DNA sequence data and the development of new methods of analysis have finally made this question tractable. Here, I review the current state-of-play of the field. Initial estimates in Drosophila suggest that approximately 50% of all amino acid substitutions, and a substantial fraction of substitutions in non-coding DNA, have been fixed as a consequence of adaptive evolution. Estimates in microorganisms are even higher. By contrast, there is little evidence of widespread adaptive evolution in our own species.

PMID:
16820244
DOI:
10.1016/j.tree.2006.06.015
[Indexed for MEDLINE]

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