Send to

Choose Destination
J Am Chem Soc. 2006 Jul 12;128(27):8742-3.

Highly selective room-temperature copper-catalyzed C-N coupling reactions.

Author information

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.


Through the use of cyclic beta-diketones as supporting ligands, the copper-catalyzed coupling of aryl iodides with aliphatic amines occurs at room temperature in as little as 1 h. These high reaction rates allow for the coupling of a wide range of aryl and heteroaryl iodides at room temperature. This method is highly tolerant of a number of reactive functional groups, including -Br and aromatic -NH2 as well as phenolic and aliphatic -OH. The high selectivity of the CuI-beta-diketone catalyst for aliphatic amines represents a useful complement to the palladium-based methods.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for American Chemical Society
Loading ...
Support Center