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J Bioinform Comput Biol. 2006 Apr;4(2):357-72.

Analysis of conserved hydrophobic cores in proteins and supramolecular complexes.

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Gamaleya Institute of Epidemiology and Microbiology, Gamaleya Str. 18, Moscow 123098, Russia.


The conserved hydrophobic core is an important feature of a family of protein domains. We suggest a procedure for finding and the analysis of conserved hydrophobic cores. The procedure is based on using an original program called CluD ( Conserved hydrophobic cores of several families including homeodomains and interlock-containing domains are described. Hydrophobic clusters on some protein-DNA and protein-protein interfaces were also analyzed.

[Indexed for MEDLINE]

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