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Nat Neurosci. 2006 Aug;9(8):1001-3. Epub 2006 Jul 2.

Cross-modal regulation of synaptic AMPA receptors in primary sensory cortices by visual experience.

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1
Department of Biology, University of Maryland, College Park, Maryland 20742, USA.

Abstract

Lack of a sensory input not only alters the cortical circuitry subserving the deprived sense, but also produces compensatory changes in the functionality of other sensory modalities. Here we report that visual deprivation produces opposite changes in synaptic function in primary visual and somatosensory cortices in rats, which are rapidly reversed by visual experience. This type of bidirectional cross-modal plasticity is associated with changes in synaptic AMPA receptor subunit composition.

PMID:
16819524
PMCID:
PMC1905492
DOI:
10.1038/nn1725
[Indexed for MEDLINE]
Free PMC Article
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