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Haematologica. 2006 Jul;91(7):964-7.

Clinical and biological features of multiple myeloma involving the gastrointestinal system.

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Myeloma Institute for Research and Therapy, Division of Gastroenterology, The University of Arkansas for Medical Sciences, 4301 West Markham Street/Slot 776, Little Rock, Arkansas 72205, USA.


We report 24 cases of multiple myeloma (MM) with involvement of the gastrointestinal (GI) system. We found a strong association with high A lactate dehydrogenase levels, plasmablastic morphology, and A unfavorable karyotype. GI involvement at the time of initial diagnosis was much rarer than later in the course of the disease. The A median survival after diagnosis of GI involvement was 7 months. Among 13 patients treated with stem cell transplantation, the response rate was 92%, and median progression-free survival was 4 months. We conclude that MM involving the GI system is associated with adverse biological features and with short-lasting remissions, even after A high-dose chemotherapy.

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