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Neurol Sci. 2006 Jun;27(2):118-21.

Creutzfeldt-Jakob disease presenting as corticobasal degeneration: a neurophysiological study.

Author information

1
Department of Neurosciences, Ophthalmology & Genetics, University of Genoa, Via de Toni 5, I-16132, Genoa, Italy.

Abstract

Creutzfeldt-Jakob disease (CJD) can occasionally present with a clinical picture resembling a corticobasal degeneration (CBD). Transcallosal inhibition, as tested by focal transcranial magnetic stimulation, is frequently absent or highly disrupted in CBD patients. We report a case of CJD presenting at the beginning of the disease as a CBD in which the ipsilateral silent period (iSP) was present and well detectable. This brief report shows that study of the iSP may be a useful diagnostic tool in order to differentiate CBD from syndromes presenting with similar clinical features.

PMID:
16816909
DOI:
10.1007/s10072-006-0611-1
[Indexed for MEDLINE]

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