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AIDS. 2006 Jun 12;20(9):1330-2.

Detection of mycobacterial antigen responses in lung but not blood in HIV-tuberculosis co-infected subjects.

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1
Department of Immunology, Royal Free & University College Medical School, Royal Free Hospital, London, UK. r.breen@medsch.ucl.ac.uk

Abstract

Forty-seven HIV-infected adults had broncho-alveolar lavage stimulated with purified protein derivate of Mycobacterium tuberculosis. Eighteen of 19 (95%) with tuberculosis co-infection had interferon-gamma synthetic CD4 lymphocyte responses > 1% versus three of 28 (11%) without (P < 0.0001). Lung response was unrelated to blood CD4 cell count. BAL HIV tuberculosis responses were similar in 25 HIV-uninfected tuberculosis patients. Responses in matched blood samples were often undetectable. Therefore, immunological tuberculosis assays seem less affected by HIV co-infection when lung-based.

[Indexed for MEDLINE]

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